Author(s): Patil PA
Endometrial cancers are one of the most common cancers in women overall, and in the developed world form the most common malignancy in the gynecologic system. They have a heterogeneous in morphology, have varying genetic profiles, and differ in clinical outcomes. Microsatellite instability (MSI) testing is becoming increasing important in a number of tumors. The National Comprehensive Cancer Network recommended MSI testing in all endometrial carcinomas. MSI can be sporadic or associated with Lynch Syndrome to harbor risk for other malignancies, requiring screening. Recently four molecular subtypes of endometrial carcinoma were reported with implications for prognosis and therapy, the four subtypes including MSI hypermutated, POLE, copy number low and copy number high. This short review discusses testing for mismatch repair deficiency in endometrial carcinomas
